Projects
Name
[Sfax]The role of deamidated gliadin peptide antibodies in the diagnosis and the follow-up of the celiac disease
University
Tunisia (ASSOCIA-MED) - University of Sfax/ Faculty of Medecine of Sfax, Sfax
Domain
Immunology
Departement
The immunology laboratory Habib Bourguiba university hospital of Sfax, Tunisia
Head
Pr. Hatem Masmoudi
Tutor
Dr. Hend Hachicha
Languages
English - French
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes No No No No Yes Yes No No No No No
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Early diagnosis as well as screening of asymptomatic forms of celiac disease associated to a gluten free diet can cure this enteropathy and avoid the developing of other autoimmune diseases. That’s why, it is essential to demonstrate the role of deamidated gliadin peptide antibodies in the diagnosis as well as in the follow of the celiac disease.
What is the aim of the project?
This project aims to study and determine the best combination of immunologic tests based on the search of deamidated gliadin peptide antibodies to ensure the most adequate diagnosis and follow up of celiac patients.
What techniques and methods are used?
 Indirect immune-fluorescence: Search of Anti-Endomysial Antibodies  ELISA: Search of deamidated gliadin peptide antibodies and anti- transglutaminase antibodies  Immunonephelometry: Dosing IgA in the serum
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Practice the different immunologic tests based on the search of deamidated gliadin peptide antibodies (after a period of learning),  Gather clinical informations,  Analyze and interpret the results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Preliminary readings in French or English will be provided to the exchange student at the beginning of his exchange period.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
- A white coat is obligatory for this clinical project.
- There are approximately 6 hours of work per day.
- The exchange students participating in this project should be a medical student who has already studied Immunology, Pediatrics and Gastroenterology.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
Articles
- Dosage des anticorps anti-transglutaminase dans le diagnostic de la maladie cœliaque de l’enfant : résultats d’une étude prospective sur cinq ans. Annales de Biologie Clinique; 2004; 62: 431–6.