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Role of single nucleotide polymorphisms of interferon related genes in the pathogenesis of Sjogren
Greece (HelMSIC) - National and Kapodistrian University of Athens, Athens
Department of Physiology, School of Medicine, University of Athens
Prof. Michael Koutsilieris
Ass. Prof. Clio P. Mavragani
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Primary Sjogren;s syndrome (pSS) is a common chronic autoimmune disease affecting 0.5-1% of population. It is characterized by lymphocytic infiltration of exocrine glands mainly salivary and lacrimal resulting in oral and ocular dryness, although any organ system can virtually be affected. A cardinal feature of primary SS is B-cell hyperactivity, manifested by the presence of hypergammaglobulinemia and various autoantibodies with B-cell activating factor (BAFF), a survival factor for B-cells, being a central contributor. Depending on the underlying pathophysiological mechanisms, pSS related systemic manifestations can be largely classified into those related to the presence of periepithelial infiltrates in exocrine and parenchymal organs and to those resulting from immunocomplexes deposition as a result of B-cell hyperactivity (purpura, peripheral neuropathy, glomerulonephritis). The latter connotes a disease subset affecting approximately 10% of patients associated with increased risk for B-cell lymphoma development and high mortality rates (high risk phenotype). Among all autoimmune diseases, pSS has the highest risk for development of non-Hodgkin;s lymphoma. Unfortunately, no preventative strategy to date is available for the high risk pSS subset.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will take active part in the clinical examination
- If the project is clinical
- the student will be allowed to work with patients
What are the tasks expected to be accomplished by the student?
Assist in the Lab Work of the project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Senior medical student (4th to 6th year) would be ideal.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Vakaloglou K.M. Mavragani C.P. Activation of the type i interferon pathway in primary Sjogren's syndrome: An update (2011) Current Opinion in Rheumatology 23 (5) pp. 459-464.
- Mavragani C.P. Moutsopoulos H.M. The geoepidemiology of Sjogren's syndrome (2010) Autoimmunity Reviews 9 (5) pp. A305-A310.
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