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Protein sorting by clathrin adaptors
Germany (bvmd) - Universitaet zu Koeln, Cologne
Institute of Biochemistry, Joseph-Stelzmann-Strasse 52, 50931 Koeln
Prof. Dr. Angelika Noegel
Prof. Dr. Stefan Hoening
Fluent English, German
Type of Research Project
- Basic science
What is the background of the project?
The clathrin adaptors bind cargo membrane proteins for packaging into transport vesicles and therefore play important roles in the biosynthetic and endocytic pathways in all cells of our body. Dysfunction of clathrin adaptors is associated with a number of rare diseases or even lethal.
What is the aim of the project?
We are trying to understand the mechanisms that regulate transport vesicle formation and sorting of cargo proteins to their appropriate place of function. Our main focus is on the so called family of heterotetrameric clathrin complexes AP-1 to AP-5.
What techniques and methods are used?
We use mammalian cells for questions related to the cell biology of clathrin adaptos. We perform transport assays, localization studies with immunofluorescence and interaction studies. Biochemical assays include protein expression and purification for various biophysical measurements and membrane lipid interaction studies.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, especially seminars and lectures and discussions with external experts.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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