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Molecular Mechanisms Of the Cellular Response to Hypoxia
Greece (HelMSIC) - University of Thessaly, Larissa
Laboratory of Biochemistry, Faculty of Medicine, University of Thessaly
Prof. George Simos
Dr Ilias Mylonis (Lecturer) & Aggeliki Karagiota (PhD Student)
Type of Research Project
- Basic science
What is the background of the project?
Background Information: The project involves the study of activation and function of the hypoxia-inducible transcription factors (HIFs) and their involvement in carcinogenesis using biochemical, molecular and cell biological methodologies and experimental approaches. For further information please visit the website of the laboratory at http://www.med.uth.gr/biochemistry/research_en.html Aim of the project: The project aims at understanding the regulation of HIF-1α by phosphorylation and nucleocytoplasmic transport and clarifying its role in cellular survival, proliferation and apoptosis in adenocarcinoma and hepatocarcinoma cells. Techniques used: Construction of DNA plasmids, production of human recombinant proteins in bacteria, human cancer cell culturing and transfection, protein and DNA electrophoresis, immunofluorescent microscopy etc.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Assist in the Lab Work of the project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Theoretical teaching provided: Preliminary Readings The student should have the elementary practical skills taught at university laboratory courses and should have successfuly attended basic preclinical courses such as Biochemistry, Cell Biology, Physiology and Pharmacology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Mylonis I. Chachami G. Paraskeva E. and G. Simos (2008) Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK. Journal of Biological Chemistry 283. 27620-27627.
- Kalousi A. Mylonis I. Politou A. Chachami G. Paraskeva E. and G. Simos (2010) Casein kinase 1 regulates human hypoxia-inducible factor HIF-1. Journal of Cell Science 123. 2976-2986.
- Mylonis I.. Sembongi H. Befani C. Liakos P. Siniossoglou S. and G. Simos (2012) Triglyceride accumulation under hypoxia involves HIF-1-dependent regulation of lipin 1. Journal of Cell Science 125. 3485-3493.
- Keith B. Johnson RS. Simon MC (2012) HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression. Nat Rev Cancer 12: 9-22.
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