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Effects of Endocannabinoids on secondary neuronal injury
Germany (bvmd) - Martin-Luther-Universitaet Halle-Wittenberg, Halle a.d.Saale
Department of Anatomy and Cell Biology, Section Neuroanatomy/University of Halle a.d.Saale
Prof. Dr. Faramarz Dehghani
Dr. U Grabiec, C. Ghadban
Fluent English, German
Type of Research Project
- Basic science
What is the background of the project?
Pathological events within the central nervous system like trauma or stroke involve in-flammatory processes that strongly account for further neurodegeneration, a process called secondary neuronal damage. Endocannabinoids, a group of endogenously synthesized lipid mediators, have been shown to form an intrinsic protective system within the brain modulating the activity and function of neurons and glial cells. Classical endocannabinoids like 2-Arachidonoyl glycerol (2-AG) are known to exert neuroprotective effects after brain injuries.
What is the aim of the project?
The aim of the present project is the characterization of neuroprotective potential of one of the members of the endocannabinoid family, namely N-arachidonoyl glycin (NAGly). In organotypic hippocampal slice cultures, primary cell culture and various cell lines. The effects of the exogeneously applied NAGly of cell survival and demise, proliferation and migration will be addressed.
What techniques and methods are used?
Cell culture, Western blot, Immunhistochemistry and PCR
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
To be negotiated. Relevant literature for understanding and performing the experiments will be provided. There are no legal limitations in the student.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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