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Acute lung injury/ARDS. Role of phospholipids
Spain (IFMSA-SPAIN)-University Complutense of Madrid, Madrid
Dept. of Pharmacology. School of Medicine. Universidad Complutense de Madrid.
Maria Isabel Colado
English and/or Spanish.
Type of Research Project
- Basic science
What is the background of the project?
Acute lung injury/Acute respiratory Distress Syndrome is one of the leading causes of death for which there is no effective treatment. The fundamental mechanisms that initiate and propagate lung injury have not been defined completely. Sphingolipids are known to function as intracellular second messengers as well as extracellular mediators involved in many physiological processes, including innate immunity, cell proliferation and apoptosis, and hypoxic pulmonary vasoconstriction. Activation of the lysosomal acid sphingomyelinase (aSMase) is a suggested mechanism responsible for the lipopolysaccharide-induced clustering of toll like receptor (TLR4) and downstream molecules and TLR2 signalling.
What is the aim of the project?
Identify the pathophysiological role of sphingolipids in ALI/ARDS and the potential therapeutic value of drugs interfering with acid sphingomyelinase in animals models including LPS- and hemorrhagic shock-induced ALI/ARDS and in in vitro systems using animal and human cells.
What techniques and methods are used?
Vascular contractility in vitro, determination of reactive oxygen species, smooth muscle cell culture, hemodynamic measurements, western blotting, PCR, Lung histology, patch clamp...
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Routine techniques at the laboratory: Vascular contractility in vitro, determination of reactive oxygen species, smooth muscle cell culture, hemodynamic measurements, western blotting, PCR, Lung histology, patch clamp...
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No theoretical teaching provided
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Pulmonary Vascular Dysfunction Induced by High Tidal Volume Mechanical Ventilation. Menendez C; Martinez-Caro L; Moreno L; Nin N; Moral-Sanz J; Morales D; Cogolludo A; Esteban A; Lorente JA; Perez-Vizcaino F. Crit Care Med. 2013 Mar 19.
- Different patterns of pulmonary vascular disease induced by type 1 diabetes and moderate hypoxia in rats. Moral-Sanz J; Lopez-Lopez JG; Menendez C; Moreno E; Barreira B; Morales-Cano D; Escolano L; Fernandez-Segoviano P; Villamor E; Cogolludo A; Perez-Vizcaino F; Moreno L. Exp Physiol. 2012 May;97(5):676-86.
- Neutral sphingomyelinase; NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction. Frazziano G; Moreno L; Moral-Sanz J; Menendez C; Escolano L; Gonzalez C; Villamor E; Alvarez-Sala JL; Cogolludo AL; Perez-Vizcaino F. J Cell Physiol. 2011 Oct;226(10):2633-40.
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