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[Monterrey] Association of polymorphisms in the genes MAD1 and MTHFR with increased chromosomal instability in the mothers of children with Down Syndrome.
Universidad Autonoma de Nuevo Leon
Department of Genetics. Medicine School. Av. Francisco I. Madero Pte. and Dr. E. Aguirre P
Larua Elia Martinez Garza
Ma. Del Roble Velasco Campos
English and spanish
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
This project deals the chromosomal instability and two polymorfisms, MAD1 and MTHFR, in mothers of child with Down syndrome compared with control group. Data suggesting that
abnormal folate and methyl metabolism are associated with the risk of Down syndrome. And was observed an increased frequency of both micronucleated cells (MN) and chromosome malsegregationevents in peripheral lymphocytes of mothers of DS
individuals aged less than 35 years at conception inrespect to controls. What is the aim of the project?Investigate about genetic factors and their paper in this pathology. To evaluate chromosome damage, measured by means of the micronucleus assay and those polymorfisms implicated in the segregation (MAD1) and folate metabolism (MTHFR).
What is the aim of the project?
Investigate about genetic factors and their paper in this pathology. To evaluate chromosome damage, measured by means of the micronucleus assay and those polymorfisms implicated in the segregation (MAD1) and folate metabolism (MTHFR).
What techniques and methods are used?
Cytologic: Micronuclei (MN) and sister chromatid exchanges (SCE) in human lymphocytes, Molecular: RFLPs for MAD1 and MTHFR polymorphisms.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Written report for the end of the exchange.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes, lectures about this project
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge about genetic and cellular biology. Basic concepts about mitosis, cell cycle, chromosomes.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- American Journal of Medical Genetics Part A 143A:2006–2015(2007). Mitotic checkpoints and the maintenance of the chromosome karyotype_ Ilse Decordier; et al. Mutation Research 651 (2008) 3–13.
- Polymorphisms in Folate and Homocysteine Metabolizing Genes and Chromosome Damage in Mothers of Down Syndrome Children; Fabio Coppede et al.
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