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A study on the regenerative potential of the mammalian retina
Tokyo Women's Medical University
Department of Anatomy, Tokyo Women
Prof. Hiroki Fujieda
Dr. Hiroki Fujieda, Dr. Norihiro Sudou_
Type of Research Project
- Basic science
What is the background of the project?
Muller glia are the principal glial cell type in the retina, which support the function of retinal neurons. Recent evidence indicated that Muller glia are retinal stem cells with a potential to regenerate neurons in the damaged retina. Although robust in lower vertebrates like fish, the regenerative capacity of Muller glia is extremely limited in mammals.
What is the aim of the project?
The aim of the project is to understand the mechanisms underlying the limited regenerative capacity of mammalian retina and to explore the strategy to promote retinal regeneration.
What techniques and methods are used?
We use Animal models (mice and rats) of retinal degeneration will be used. Expression of proteins and mRNA will be analyzed by immunohistochemistry, western blotting, RT-PCR, etc. both in vivo and in vitro.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will learn techniques essential for basic biomedical research, such as immunohistochemistry and western blotting.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must have experience in basic research practices such as pipetting and knowledge on the basic histology of the retina and the principles of immunohistochemistry, western blotting and PCR techniques. Additionally we prefer student are used to recent hot topics in neuroscience through lab works, discussion and paper reading.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Karl and Reh (2010) Trends in Molecular Medicine 16(4)193-202.
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