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Role of prostaglandins in the hypothalamic paraventricular nucleus in the stress-inducedelevation of plasma catecholamines
Japan (IFMSA-Japan) - Aichi Medical University, Aichi
Dept of Pharmacology, Aichi Medical University
Shoshiro Okada, Naoko Yamaguchi
Type of Research Project
- Basic science
What is the background of the project?
Prostaglandins in the brain, especially in the hypothalamic paraventricular nucleus (PVN) play critical roles in the central regulation of autonomic functions. Project background information for the interested students: Theoretical thinking and training experience will in the long run be a beneficial skill that could be applied in many areas of research and clinical practice.
What is the aim of the project?
The aim of the project is to investigate whether endogenous prostaglandins in the PVN are produced in the stress conditions such as immobilization by using brain microdialysis technique combined with LC-MS method.
What techniques and methods are used?
such as brain microdialysis, immunohistochemistry, LC-MS, HPLC-ECD. At least one of the above techniques will be used.
What is the role of the student?
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
The students will acquire skills on basic medical science that could be used for almost every field of biology.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No theoretical teaching provided.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Students will be required to have knowledge of basic medicine and early clinical practice taught in medical school. No legal limitations are required in the project.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- _1) Alpha-1 adrenoceptor activation is involved in the central N-methyl- D aspartate- induced . adrenomedullry outflow in rats. Authors: Shoshiro Okada; Naoko Yamaguchi; European Journal of Pharmacology : 640(1-3):55- 62. (2010)
- 2) Perfusion of the hypothalamic paraventricular nucleus with N-methyl- D aspartate produces thromboxaneA2 and centrally actovates adrenomedullary outflow in rats. Authors: Okada S; Murakami Y; Nishihara M; Yokotani K; Osumi Y; Neuroscience 96(3):585-590; 2000
- 3) Search with Pub Med
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