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Neurobiology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")
Spain (IFMSA-SPAIN)-University Complutense of Madrid, Madrid
Department of Pharmacology, Faculty of Medicine, Universidad Complutense, 28040 Madrid
Prof. Isabel Colado
Prof. Isabel Colado
Type of Research Project
- Basic science
What is the background of the project?
Drugs of abuse such as amphetamine derivates (MDMA and methamphetamine) are widely consumed by young people both alone and in combination. Animal studies have shown that these drugs produce neurotoxicity and neuroinflammation and these effects have also been reported in humans.
What is the aim of the project?
Study the mechanisms involved in the neurotoxicity and neuroinflammation induced by MDMA and methamphetamine given alone or in combination with ethanol in laboratory animals.
What techniques and methods are used?
Western blot, immunohistochemistry/immunofluorescence, ELISA, zymography, HPLC, radioligand binding, in vivo experimentation, biochemical assays.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
- Acquisition of the laboratory techniques involved in the study and once validated - participation in some of the assays. The practical skills and the knowledge the student will acquire during the exchange program will be Practical skills (sample handling and preparation, general laboratory skills, centrifugation, electrophoresis, immunoblotting, section preparation, liquid handling, chromatiography...) and knowledge (background related to the field). There are approximately 8 hours of work per day.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be no theoretical teaching provided but background reading will be advised.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Pre-Medical students from the American-British system
- Urrutia et al; Neurobiol. Dis. 50: 49-58; 2013
- Mayado et al; J. Neuroinflam. 8:165; 2011
- Torres et al; J. Neuroinflam. 8:53; 2011
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