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Determination of novel G-protein regulators involved in disease development.
Japan (IFMSA-Japan) - Aichi Medical University, Aichi
Physiology, Aichi Medical University,
Motohiko Sato, MD, PhD
Motohiko Sato, MD, PhD
Type of Research Project
- Basic science
What is the background of the project?
The G-protein signaling system plays important roles in signal integration of physiological stimuli including hormones/neurotransmitters to maintain homeostasis of the cardiovascular system. In addition to traditional components of G-protein signaling such as G-protein coupled receptor (GPCR), heterotrimeric G-proteins and effectors, recent data indicate the existence of accessory proteins that directly regulate the activation status of G-proteins independent of GPCR.
What is the aim of the project?
To determine novel signal regulator which influence activation of heterotrimeric G-protein from disease-based models.
What techniques and methods are used?
The activator of heterotrimeric G-proteins will be screen in the expression-cloning system in yeast as P.I. used in several manuscripts. The function of G-protein activators will be examined examined in vivo and in the mammalian cells. Special remarks: I, Motohiko Sato worked in United Sates over 7 years as post doctoral fellow and assistant professor. I just moved to Aichi Medical University and launched the new laboratory. The student will be welcomed as the first foreign visiting-scientist/student.
What is the role of the student?
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
The students will acquire skills of universal techniques of basic sciences useful in other research field.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There is theoretical teaching provided.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
SStudents will be required basic knowledge of basic sciences, including signal transduction, pharmacology and physiology. No legal limitation are required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- Hayashi H; Mamun AA; Sakima M; Sato M. Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing in angiogenesis. Journal of Cell Science 129: 1210-1222; 2016.
- Sato M; Hiraoka M; Suzuki H; Bai Y; Kurotani R; Yokoyama U; Okumura S; Cismowski MJ; Lanier SM; IshikawaY. J Biol Chem. 2011 286(20):17766-76.
- Sato M; Jiao Q; Honda T; Kurotani R; Toyota E; Okumura S; Takeya T; Minamisawa S; Lanier SM; Ishikawa Y _ J. Biol. Chem. 2009 284(45):31431-40.
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