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Analysis of the physiological role of the bile acid-sensitive ion channel BASIC in the bile duct epithelium
Germany (bvmd) - Rheinisch-Westfaelische Technische Hochschule, Aachen
Institute of Physiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen
Prof. Dr. Stefan Gruender
Dr. Dominik Wiemuth
Fluent English, German
Type of Research Project
- Basic science
What is the background of the project?
he bile acid-sensitive ion channel BASIC is expressed in cholangiocytes, the epithelial cells lining the bile ducts. The physiological function of BASIC in this primarily secretory epithelium is completely unknown.
What is the aim of the project?
Examine the role and physiological function of BASIC in primarily secretory epithelium.
What techniques and methods are used?
We employ a combination of electrophysiological methods, like Xenopus oocyte two-electrode voltage-clamp, patch-clamp and Ussing chamber along with molecular and cell biological methods to address this question
What is the role of the student?
What are the tasks expected to be accomplished by the student?
We will design a project that the student will work on under the supervision of an experienced scientist. Ideally, the project will contribute significantly to the progress of the whole group.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic laboratory experience would be a plus. For the use of students considering participating in the project, further information can be found from the following articles: 1) Wiemuth D., Sahin H., Falkenburger B., Lefèvre C. M. T, Wasmuth H. and Gründer S. (2012) BASIC - a bile acid-sensitive ion channel highly expressed in bile ducts. FASEB J, 26(10):4122-30 2) Wiemuth D. and Gründer S. (2011) The Pharmacological Profile of Brain Liver Intestine Na+ Channel (BLINaC): Inhibition by Diarylamidines and Activation by Fenamates. Mol Pharm 80(5):911-919 3) Wiemuth D. and Gründer S. (2010) A single amino acid tunes Ca2+ inhibition of Brain Liver Intestine Na+ Channel (BLINaC). J Biol Chem 285(40):30404-30410
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- University of Aachen
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