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Studying the molecular and cellular mechanisms driving regeneration processes at the neurovascular interface
Germany (bvmd) - Albert-Ludwigs-Universitaet, Freiburg
Department of Molecular Embryology, Institute of Anatomy and Cell Biology
Prof. Dr. Kerstin Krieglstein
Dr. Christian Schachtrup
Type of Research Project
- Basic science
What is the background of the project?
Background: After brain injury or neurologic disease, the ability of the central nervous system (CNS) to regenerate is limited. In physiology, a physical and metabolic barrier between the brain and the systemic blood circulation, namely the blood-brain barrier (BBB), inhibits the entry of blood proteins from the vasculature into the nervous system. Upon CNS injury or disease the brain vasculature becomes permeable to blood proteins and similar to other organs blood proteins leak in the brain parenchyma.
What is the aim of the project?
We are specifically interested in cell responses driven by an altered environment in CNS disease with Blood-Brain Barrier opening. We aim to understand how changes in the environment translate into cell signaling and transcriptional programs regulating regeneration mechanisms. Our ultimate goal is to elucidate novel targets for therapeutic intervention.
What techniques and methods are used?
We are using histopathology, microscopy, biochemistry, primary cell culture and animal models for CNS diseases with Blood-Brain Barrier opening to address the biological complexity of disease and repair mechanisms.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Requirements: Basic laboratory experience, experience with cell culture work, good knowledge in neuroscience - For the use of students considering participating in the project, further information can be found from the following articles: 1. Schachtrup et al., 2010. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage. J Neurosci 30:5843-5854. 2. Adams et al., Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr Med Chem 14:2925-2936. 3. Silver, J. & Miller, J. H. Nat Rev Neurosci 5, 146-156, (2004). 4. Ming GL, Song H (2011) Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 70:687-702. - Phone interview (Skype) with the Principal Investigator is required prior to acceptance.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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