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Chemotaxis and relationships between the inflammatory and the autophagy components in Alzheimer's Disease
France (ANEMF) - Universite de Poitiers
EA 3808, molecular targets and therapeutic in Alzheimer's Disease
Pr. Guyl&#232;ne PAGE
A. RIOUX-BILAN, T. JANET, B. FAUCONNEAU, F. TERRO
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Research of molecular mechanisms involved in chemotaxis of
peripheral blood cells to the CNS.
Relationships between inflammations and autophagy in AD For these two axes, research is translational, from cell to patients.
The aim of the project is to define chemotaxis signature in AD, to demonstrate the role of inflammation in alterarions of autophagy and to find molecular targets for diagnosis and therapeutics.
Differents techniques will be used : Cell culture, Western Bots, ELISA multiplex, qPCR,immunohistochemistry, various work on animal models, behavioural tests, methods of extraction of peripheral blood cells, enzymatic activities.
The student have to know molecular and cellular biology and have beforehand knowledge of various research therapeutic applications in Alzheimer's disease.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will mainly observe
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must make sure he/she has legal authorization to work
with animals (if not, he/she can still apply to the projet, but will not participate in dissections).
Tutors will provide some review about the subject directly to the
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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