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Analysis of the effect of RGD analogs on cell proliferation
France (ANEMF) - University of Rennes, Rennes
Kidney cancer : Molecular basis of tumorigenesis
ARLOT-BONNEMAINS Y & VIGNEAU C
Pr BELAUD-ROTUREAU Marc Antoine
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Renal cell carcinoma (RCC) is the seventh most common cancer worldwide in humans corresponding to approximately 3% of cancers in adults. The incidence has steadily increased in recent years, varies across countries, the higher rates being recorded in the European Nordic countries and North America. Approximately 210,000 new cases were diagnosed in 2009 in the United States with over 100,000 deaths (Rini et al., 2009). In France, 12,000 new cases are recorded every year with an estimated number of deaths around 4500 (Hill et al., 2008). Risk factors are now well known and in particular include smoking, obesity, chronic renal failure, renal transplantation or Von Hippel Lindau (VHL) gene mutations. Disruption of VHL, by somatic mutation, promoter silencing (by hypermethylation) or chromosomal loss, is also found in the majority of cases of sporadic clear cell Renal Cell Carcinoma (ccRCC), the main subtype of kidney cancer.
What is the aim of the project?
We propose to functionally analyse the uncharacterized VHL mutations which have been identified in the CRB of Rennes (ccRCC patients)
What techniques and methods are used?
The tutor didn't say.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
to analyse the uncharacterized VHL mutations which have been identified in the CRB of Rennes (ccRCC patients)
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good knowledges in cell biology are required for the project.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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