Projects
Name
Genetic and genomic mapping of human bacterial pathogens
University
Czech Repiblic (IFMSA CZ) - Masaryk University, Brno
Domain
Biology
Departement
Department of Biology
Head
Prof. Ing. Petr Dvorak, CSc.
Tutor
Doc. MUDr. David Smajs, Ph.D.
Languages
English
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes No
Type of Research Project
- Basic science
What is the background of the project?
The main aim of the project is to identify virulence determinants of selected bacterial species including E. coli and T. pallidum. Knowledge of these virulence determinats can help to find the right treatment for disease caused by these bacterial species.
What is the aim of the project?
The project is aimed mainly on finding these virulence determints by using methods of molecular biology and genomic methods.
What techniques and methods are used?
Basic laboratory methods and selected advanced laboratory techniques.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will learn laboratory methods used in molecular genetics and genomics. A conference lecture or poster is expected
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
For the use of students considering participating in the project, further information can be found from the following articles: Šmajs, D., Micenková, L., Šmarda, J., Vrba, M., Ševčíková, A., Vališová, Z., Woznicová, V. 2010. Bacteriocin synthesis in uropathogenic and commensal Escherichia coli: colicin E1 is a potential virulence factor. BMC Microbiology 10:288. Mikalová, L., Strouhal, M., Čejková, D., Zobaníková, M., Pospíšilová, P., Norris, S. J., Sodergren, E., Weinstock, G. M., Šmajs, D. 2010. Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are localized in six genomic regions. PLoS ONE 5(12): e15713.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic laboratory methods (as PCR, electroforesis, cultivation, western blot, northern blot) and selected advanced laboratory techniques.

For the use of students considering participating in the project, further information can be found from the following articles:
Šmajs, D., Micenková, L., Šmarda, J., Vrba, M., Ševčíková, A., Vališová, Z., Woznicová, V. 2010.
Bacteriocin synthesis in uropathogenic and commensal Escherichia coli: colicin E1 is a potential
virulence factor. BMC Microbiology 10:288.
Mikalová, L., Strouhal, M., Čejková, D., Zobaníková, M., Pospíšilová, P., Norris, S. J., Sodergren, E.,
Weinstock, G. M., Šmajs, D. 2010. Genome analysis of Treponema pallidum subsp. pallidum and subsp. pertenue strains by whole genome fingerprinting: most of the genetic differences are
localized in six genomic regions. PLoS ONE 5(12): e15713.
Are there any legal limitations in the student’s involvement
No
Hours
6
Type of students accepted
This project accepts:
- Medical students
Articles
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