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Manifestations of Hepatitis C among Bilharziasis patients.
Egypt (IFMSA-Egypt) - Suez Canal University, Suez Canal
Internal medicine department, Suez Canal University hospital.
Prof.Dr. Asem Elsherif - Dr Nader Negm
Type of Research Project
- Global Action Project (GAP)
What is the background of the project?
Hepatitis C virus (HCV) infection with concurrent Schistosoma infestation has emerged as a major cause of chronic liver disease and liver cirrhosis. Our data shows that a good proportion of patients with bilharziasis had HCV infection. The percentage positive for HCV antibody were the highest in Egyptians. Clinical studies in Suez Canal university hospitals showed 70% to 90% of patients with chronic hepatitis, cirrhosis, or hepatocellular carcinoma had HCV infections. Co-infections with Schistosomiasis caused more severe liver disease than infection with HCV alone. Different diagnostic radiological and laboratory techniques will be used such as using enzyme linked immunosorbent assay for HCV infection and indirect hemagglutination tests for Schistosoma infestation,CT, ultrasound, MRI, liver biopsy, liver functions test, and other blood tests.
What is the aim of the project?
The aim of this study is to investigate the prevalence of HCV among bilharzia patients.
What techniques and methods are used?
Evaluation included abdominal ultrasonography; detection of anti-HCV antibodies and markers of HBV and HDV infection; HCV-RNA assay by 5' untranslated region nested polymerase-chain- reaction and HCV genotyping by a line probe assay; serologic (anti-soluble egg antigen, anti-SEA) and parasitological examinations for Schistosoma mansoni infection; and liver biopsy, if not contraindicated.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Collecting medical history. Performing general and local examination. Collecting blood samples for lab measurements. Integrating in investigations of HCV and Shistosomiasis and then contributing in giving results. Study and explain the basics of chronic liver disease and its causes.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be a training at the beginning of exchange in the form of lectures and seminars in microbiology , parasitology and tropical medicine . Then the student will participate in field work through attending presentation of patients , participating in clinical examination , diagnosis and management of patients . The student will attend the presentation of the patient, different examination techniques, follow up, different diagnostic methods and will attend the operative management of those patients and follow up postoperative results.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student must have studied microbiology, pathology, and preferred hepatology, with further reading about hepatitis C and Bilharziasis.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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