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Functional genomics of carbonic anhydrases.
Finland (FiMSIC) - University of Tampere, Tampere
University of Tampere, Department of Health and Life Sciences
Professor Seppo Parkkila
Ashok Aspatwar, Harlan Barker, Linda Urbanski, Maarit Patrikainen
Type of Research Project
- Basic science
What is the background of the project?
Carbonic anhydrases are enzymes which are mainly involved in the regulation of acid-base homeostasis in all cell types. They form at least seven distinct enzyme families (alpha, beta, gamma, delta, zeta, eta, theta). Our studies are focused on alpha and beta carbonic anhydrases. Alphas are widely expressed in prokaryotes and eukaryotes. Beta-forms are present in prokaryotes and some eukaryotes, but not in humans. Especially the beta-carbonic anhydrases are potential targets for antimicrobial drugs.
What is the aim of the project?
The main aim is to investigate the physiological roles of various carbonic anhydrases in prokaryotic and eukaryotic organisms. We also use carbonic anhydrases as target molecules for drug design.
What techniques and methods are used?
A typical project first involves identification of a target protein using bioinformatics tools. Then we design the method for recombinant protein production in either bacteria or insect cells. The produced proteins are characterized using standard protein chemistry. In some cases, we study the function of the protein using knockout/knockdown techniques.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will actively work together with the other team members. It will be mainly reading, communicating with the others, learning new techniques, and performing actual experiments.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There are group meetings once in every two weeks.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic laboratory skills. Some experience with protein chemistry and molecular biology are appreciated. Subjects that need to be passed: Courses in cell biology, molecular biology, biochemistry
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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