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Role of sex hormones in pathogenesis of renal diseases
Slovakia (SloMSA) - Comenius University, Bratislava
Institute of Molecular Biomedicine, Medical faculty, Comenius University in Bratislava
Peter Celec, MD, MSc., Ing, PhD., MPH
Julius Hodosy, MD, MSc., PhD., MPH
Type of Research Project
- Basic science
What is the background of the project?
All but chronic and repeated acute severe kidney disease lead ultimately to the formation of renal fibrosis. It is estimated that approximately 500 million people currently suffer from kidney disease and this number is growing. In renal diseases, the tissue is firstly functional; however this is changed slowly but progressively to fibrotic non-functional tissue. Therefore, the research of renal fibrosis has its rational meaning. Same time, epidemiological studies have shown that male gender is a risk factor for the emergence and development of chronic kidney disease (chronic kidney disease, CKD) compared with premenopausal women reduce this risk. Accordingly, i tis likely that estradiol contributes to the development of renal fibrosis is high, but i tis not clearly described. The role of testosterone in the development of renal fibrosis in not known at al..
What is the aim of the project?
The project aims to establish a standardized model of renal fibrosis and contained in recurrent urinary tract infections and subsequently to describe the changes in concentrations of sex hormones in plasma and the role of sex hormones in the progression of renal fibrosis. To optimalize and standardize the model of renal fibrosis in recurrent urinary tract infections, so the planned experiments are within comparable results
What techniques and methods are used?
PCR, RT-PCR, electrophoresis, animal experiments, DNA and RNA isolation, sequencing, Animal models of renal fibrosis - Unilateral Ureteral Obstruction model - Urinary tract infection model - 5/6 nephrectomy model Methods for animal behavior measuring - Porsolt swim test - Open field test - Morris Water Maze test - Light/Dark box test - Elevated Plus Maze test - Sociability test
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
To describe on model of renal diseases - The changes in sex hormones levels in plasma - The role of sex hormones in progression of renal fibrosis
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
-Only a will to work at laboratory -Basic knowledge of good laboratory practice is suitable. -Will to work with experimental animals
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
- www.imbm.sk in section "Students studying in English" and "Publications"
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