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Regulation of ion channels by anti-aging hormone Klotho
Korea (KMSA) - Yonsei Wonju university, Gangwon province
Department of Physiology, Yonsei University Wonju College of Medicine
English or Korean
Type of Research Project
- Basic science
What is the background of the project?
Klotho is a mammalian senescence-suppression protein. Klotho-deficient mice have accelerated aging and imbalance of ion homeostasis. The central hypothesis of the project is that Klotho regulates ion channels and protects tissue injury including glomerular diseases, liver fibrosis and cancers caused by increased expression and/or activity of the channels.
What is the aim of the project?
Specific aim of this project is to examine the mechanism by which Klotho regulates ion channels. Electrophysiology, ion-imaging techniques, basic molecular and cell biology tools.
What techniques and methods are used?
-Electrophysiology and live-cell imaging -basic cell biology and molecular biology tools -in vivo experiments using genetically modified mice and diseases models.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
- The student will mainly observe
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
1. Theoretical basis of electrophysiological approach such as whole-cell patch clamp techniques and its analytic methods 2. Theoretical understanding of ion imaging including Ca2+ imaging using Fura-2 3. contribute to research project
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There is theoretical teaching provided.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation - The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Well-reading and excellent understanding of scientific literature is also required. Basic knowledge of electrophysiology, biochemistry and molecular biology is required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Cha SK/Ortega B/Kurosu H/Rosenblatt KP/Kuro-O M/Huang CL. Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding galectin-1. PNAS 2008;105(28):9805-10
- Cha SK/Hu MC/Kurosu H/Kuro-o M/Moe O/Huang CL. Regulation of renal outer medullary potassium channel and renal K+ secretion by Klotho. Mol Pharmacol 2009 76:38-46
- An SW/Cha SK/Yoon JH/Chang S/Ross EM. Huang CL. WNK1 promotes PIP2 synthesis to coordinate growth factor and GPCR-Gq signaling. Curr Biol 2011 21:1979-87
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