Projects
Name
Detection of miRNA as a prognostic factor in the outcome of colorectal cancer.
University
Catalonia (AECS) - Autonomous University of Barcelona (UAB) - Hospital Parc Tauli, Barcelona
Domain
Oncology
Departement
Medical Oncology, Sabadell University Hospital
Head
Dr. E. Grau
Tutor
Dr. Carles Pericay, Dra. Anna Brunet
Languages
English, Spanish, Catalan
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Our group is working on identification of diagnostic and prognostic biomarkers for cancer patients. MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression post-transcriptionally. MicroRNAs play a key role in diverse biological processes, including development, cell proliferation, differentiation, and apoptosis. Accordingly, altered miRNA expression is likely to contribute to human disease, including cancer. Currently we are studying miRNAs expression profile in tumoral tissue and serum samples of colorectal cancer patients with the aim to evaluate they potential value as prognostic biomarkers as well as in predicting chemotherapy response.
What is the aim of the project?
To permit to the students to know the translational investigation in colorectal cancer
What techniques and methods will be used?
RNA and DNA extraction from human tissue and blood
Quantitative reverse transcription-PCR (qRT.PCR).
What is the aim of the project?
To permit to the students to know the translational investigation in colorectal cancer
What techniques and methods are used?
RNA and DNA extraction from human tissue and blood Quantitative reverse transcription-PCR (qRT.PCR)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will participate in projects that we would be working on during the stay of the student's exchange. The student will learn translational techniques and the correlation among clinical outcome and biological outcome.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge of anatomy, and colorectal function. Minimum knowledge of laboratory techniques and more than three years of medical school are required.
Are there any legal limitations in the student’s involvement
No
Hours
7
Type of students accepted
This project accepts:
- Medical students
Articles
- http://www.ncbi.nlm.nih.gov/pubmed/20146939
- http://www.ncbi.nlm.nih.gov/pubmed/22113163