Influence of selective phosphodiesterase inhibitors and other agents on airway reactivity and cough
Comenius University Martin
Department of Pharmacology, Jessenius Faculty of Medicine, Comenius University
Assoc. Prof. Dr. Sona Franova, PhD
Assoc. Prof. Juraj Mokry, MD, PhD
English, German, Russian and Italian with limitations on the side of tutor
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes No No Yes Yes Yes Yes
Type of Research Project
- Basic science
What is the background of the project?
Non-selective phosphodiesterase (PDE) inhibitors (e.g. theophylline) are used in clinic for their antiinflammatory and bronchodialting effects. As they have many adverse effects, selective PDE inhibitors are tested - predominantly PDE3, 4 and 7. Similarly, the inetrest is in evaluation of other targets possibly used in cough threapy, i.e. alternaive antitussives - plant extracts, polysaccharides, ion channels openers and blockers.
What is the aim of the project?
The aim of the project is to evaluate the effectiveness of selective PDE4 and 7 inhibitors on cough and airway reactivity in experimental conditions. Their effectiveness will be compared with other agents from pharmacological groups with potential in cough suppression.
What techniques and methods are used?
In vivo airway reactivity assessment - guinea pigs - whole body double chamber plethysmograph. In vitro airway reactivity assessment - guinea pigs - organ bath method Evaluation of cough - chemically-induced (citric acid) in in vivo onditions - guinea pigs Markers of inflammation - ELISA, blood count, biochemical analysis of oxidation status, exhaled NO analysis.
What is the role of the student?
- The tasks of the student will be performed on his/her own
What are the tasks expected to be accomplished by the student?
will to work
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
General knowledge from physiology, pathophysiology and pharmcology of respiratory system is required.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students