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Role of different nerve fiber classes in hyperalgesia following peripheral injury
Denmark (IMCC) - Copenhagen University, Copenhagen
Rigshospitalet, Copenhagen, BRAIN Lab, Institute of Neuroscience & Pharmacology
Professor Albert Gjedde
Ron Kupers (Assoc. prof.) and Maurice Ptito (prof.)
English. No other languages are required. Danish or French would be an advantage.
Type of Research Project
- Basic science
What is the background of the project?
Studies in animals have suggested that following a peripheral nerve injury or inflammation, large myelinated fibers become responsive to thermal stimulation and may be at the basis of the increased pain perception in response to thermal stimulation. Under normal circumstances, large myelinated fibers respond to mechanical stimuli only and not to thermal stimuli. The purported role of the large diameter afferent fibers in abnormal pain perception following injury or inflammation has never been has never been confirmed in human studies.
What is the aim of the project?
The aim of the present project is to test test this hypothesis in a human pain model of central sensitization. Thereto, a mild experimental burn injury will be induced on the lower leg, using a computer-controlled Peltier heating device.
What techniques and methods are used?
Using a CO2 laser stimulator which allows to selectively stimulate small myelinated (Adelta) and unmyelinated C-fibers, we will map the responses responses of the different fiber classes before and at regular intervals following the burn injury. If the hypothesis of the animal studies is correct, we expect a shift towards faster response times (in the range of that of large myelinated fibers) following the burn injury.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Students will get preliminary readings on pain physiology and will be trained in the use of the CO2 laser. They are also expected to attend and to actively participate in the weekly staff meetings. The student is expected to run laser stimulation tests in a group of normal control subjects - to analyze and interpret scientific data.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Good knowledge of English, good organisational skills and fluid in social contacts.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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