Role of immunological mechanism in the progression of alcoholic and Non-Alcoholic Steatohepatitis
Università degli studi di Novara
Dept. of Medical Sciences, University of East Piedmont, via Solaroli 18, 28100 Novara, Ital
Prof. Emanuele Albano
Prof. Emanuele Albano
4 weeks
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No No No No No Yes No No
Type of Research Project
- Basic science
What is the background of the project?
It is increasingly recognized that inflammation has an important role in the pathogenesis of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). However, the mechanisms respinsible for maintaining hepatic inflammatory processes are still incompletely characterized. In this contest, recent evidence indicate a possible role of adaptive.
There is no objection in including the student
What is the aim of the project?
This project is aimed to evaluate the possible relationship between the presence of immune reactions toward antigens generated by the reaction hepatic protein and lipid peroxidation products and inflammatory markers in the liver of rodents receiving alcohol or a high fat diet.
What techniques and methods are used?
ELISA assays for antibody and cytokine measure, Immunohistochemistry and R-pCR.
What is the role of the student?
- The student will mainly observe
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The role of the student will be partecipating to the analysis performed in the lab taking care of simple analytical procedures,performing statistical analysis of the data generated and participating to the discussion of the results.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Background reading and introduction seminars will be provided together with technical teaching on the experimental procedures to be used
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowledge in biology, biochemistry immunology and pathology are required.
NO specific technical skill, but previous experience in lab work is welcome.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts:
- Medical students
- Graduated students (less than 6 months)
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