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Infection by HIV and by agents with mucocutaneous tropism: from pathogenesis to prevention
France (ANEMF) - University of Montpellier, Montpellier
UMR 1058 INSERM/UM1/CHU U.F.R. de Pharmacie
Philippe Van de Perre
Philippe Van de Perre, Pierre Dujols, Bernard Guillot, Olivier Dereure, Jean-Pierre Vendre
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Our research unit was created in January 2007 based on the theme "Transmission, pathogenesis and the prevention of HIV infection and its co morbidities". The research carried out is without doubt in the field of translational research in infectiology, with clinical trials and mechanistic explanatory studies in immunology and virology that precede and justify them, or explain the results. This research is mainly intended for, but nonexclusively, the international health, with numerous collaborations in Europe, Africa and Asia.
What is the aim of the project?
Our unit is structured according to new objectives of the period 2011-2014. In order to provide the complementary between clinical and explanatory aspects of our research programs, each of these topics will be animated jointly by a methodologist (in biostatistics, public health or epidemiology) or a clinical practitioner and a researcher in biology (virology, bacteriology, immuno-virology).
What techniques and methods are used?
Molecular biology (sequencing, real time PCR), immunovirology (ELISPOT, flow cytometry, confocal microscopy), cell culture, bacterial and viral culture will be used. Access to proteomic and affimetrix platforms.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Bibliography will be provided. The three topics and their animators are as follows: - Transmission and prevention of HIV (Dorine Neveu and Philippe Van de Perre). - Interaction between HIV and other infectious agents (Nicolas Nagot and Michel Segondy). - Viruses with mucocutaneous tropism (Bernard Guillot and Jean-Pierre Molès)
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
The student will acquire technical skills, intellectual creativity, methodological rigour.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a scientific report - The student will prepare an abstract
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Open-mindedness, enthusiasm, willingness for team work, basic knowledge in virology, immunology, epidemiology and infectious diseases
For the use of students considering participating in the project, further information can be found from the following articles:
In the last 4 years, four major achievements have to be credited to our team:
- The demonstration of the boosting effect of HSV-2 reactivations on HIV-1 replication in the blood and genital compartments of co infected women (Nagot N et al, New Engl J Med 2007; Van de Perre P et al, Lancet Infect Dis 2008).
- Characterization of the HIV-1 T cell reservoirs and of the memory B cells specificity in breast milk and in other anatomical compartments (Becquart P et al, AIDS 2006; Tuaillon E et al, J Immunol 2009).
- Establishment of a cohort of young highly exposed women in Ouagadougou, Burkina Faso in preparation for HIV vaccine trials (project funded by the EDCTP, conducted in collaboration with the London School of Hygiene a
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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