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ELECTROSTIMULATION, MUSCLE DISUSE AND OXIDATIVE STRESS AS DETERMINANTS OD AGE DEPENDENT CHANGES IN REGENERATIVE PROPERTIES OF MUSCLE SATELLITE CELLS
Università degli studi di Chieti
Neuroscience & Imaging - University of Chieti
Prof. G.L. Romani
Prof. S. Fulle firstname.lastname@example.org
Type of Research Project
- Basic science
What is the background of the project?
The surface electrical stimulation(ES)of human skeletal muscle has been utilized as rehabilitative therapies or for a procedure of passive training for healthy athletes or in obstuctive lung disease.It could modulate the neuromuscular plasticity and,by adequate time and intensity of application, also induce an hyperthropic response in the skeletal muscle.Although has been demonstrated that the maximum voluntary for of healthy and damaged muscle can be increased by multiple sessions of training for resitance of ES,the adaptive mechanism(s)by which this effect is established is still not much known.One of the main problems during the muscle regeneration process concernings the presence of a correct cross talking area between the terminal bottom of motoneuron and the end plate of the musclular fibre membrane.However, more of the regenerative capability of muscle tissue risides in satellite cells that are quiescent in mature skeletal muscle but following various stimuli,they are activated, proliferate and fuse to form new fibres.This process is regulated by several specific proteic growth factors as IGF-1, HGF, mIGF-1. In the aged people characterise by mass and force muscle loss (sarcopenia), also the regenerative capacity results depressed and this also increases an already compromised physical situation with inevitable reflexes on the social behaviour of an elevated number of subjects.
What is the aim of the project?
Current data points out that the development of sarcopenia is a multifactor process. Many factors, including motor-units remodelling, decreased hormone levels with consequent negative effect on protein synthesis,stress oxidative damage, satellite cells recruitment by growth factors may all contribute to sarcopenia. Appropiate stimuli,as different protocols of physical exercise, could both increase the protein synthesis and to activate satellite cells,favouring an increase of the mass. In this scenario the use of ES treatment could represent a training protocol efficient in aged people to recover the muscle mass (or at least to reduce deduce the decrease) with a benefit in force and resistance.
What techniques and methods are used?
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The role of the student will be:assistant during the experimental procedure, analysis of the data, discussion,use of electro-stimulators and EEM (Excitation - emission matrix) procedures and surgical procedures to obtain muscle biopsies.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
usual knowelage of basic medicine programs. students with at least 1-2 years of medicine courses.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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