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Pathogenesis of myotonic dystrophy
Unit of Human genetics, CRHUQ-CHUL, 2705 Bd Laurier, Quebec, G1V4G2
Type of Research Project
- Basic science
What is the background of the project?
What is the aim of the project?
The aim of the project is to identify mispliced preRNAs that are involved in the pathogenesis of myotonic dystrophy.
What techniques and methods are used?
Analysis will be based on RT-PCR, real time PCR in diseased human muscle cells and in a murine model of the disease
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The role of the student will be to participate in the analysis on specific mispliced preRNA. Depending of the results, the student will be co-author of a paper and on each presentation. The student will acquire molecular biology techniques, human cell cultures. He will also acquire the mechanisms of RNA processing.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
There is no specific skill required but a knowledge in molecular biology will be helpful.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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