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Characterization of proteins involved in epidermal barrier function and Atopic Dermatitis pathophysiology
France (ANEMF) - University of Toulouse, Toulouse
CNRS-University of Toulouse III UMR5165, CHU Purpan
Pr Guy SERRE
Dr Michel Simon
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Atopic Dermatitis (AD) is a common chronic inflammatory skin disease affecting 15-20% of children and 1-3% of adults in industrialized countries. It is often linked with other atopic conditions, such as asthma and allergic rhinitis. AD results from complex interactions between genetic and environmental factors. The pathogenesis of the disease is still poorly understood although immune system dysfunctions as well as defects in the epidermal barrier have long been suspected. A major breakthrough was the discovery that loss-of-function mutations in the gene encoding filaggrin (FLG), an essential component of the upper epidermis, are a major risk factor.
We are now looking for other genes/proteins involved in the susceptibility and/or pathophysiology of AD.
Methods used : PCR, purification of PCR fragments after agarose gel electrophoresis, sequencing, immunohistology, western, extractions of proteins
The student have to observe, understand and reproduce the techniques.
No outcome of the student's participation will be required.
The student will have a first approach of fundamental and bioclinical research programs and methodology, understanding of keratinocyte differentiation program, discovery of up-to-date biological analysis methods.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
For the use of students considering participating in the project, further information can be
found from the following articles:
1. Pellerin L, Henry J, Hsu CY, Balica S, Jean-Decoster C, Méchin MC, Hansmann B, Rodriguez E,
Weindinger S, Schmitt AM, Serre G, Paul C, Simon M. Defects of filaggrin-like proteins in both
lesional and non-lesional atopic skin.
J Allergy Clin Immunol 131:1094-1102, 2013.
2. Henry J, Hsu CY, Haftek M, Nachat R, de Koning HD, Gardinal-Galera I, Hitomi K, Balica S, Jean-
Decoster C, Schmitt AM, Paul C, Serre G, Simon M. Hornerin is a component of the epidermal
cornified cell envelopes.
FASEB J 25:1567-1576, 2011.
3. Cork MJ, et al. Epidermal Barrier Dysfunction in Atopic Dermatitis.
J Invest Dermatol 129:1892-908, 2009.
4. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, et al. Common loss-of-
function variants of the epidermal barrier protein filaggrin are a major predisposing factor for
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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