Projects
Name
Investigations on biocompatibility of modified calcium phosphates and composite materials for bone implants
University
Bulgaria (AMSB) - Medical faculty of Sofia University, Sofia
Domain
Pathology
Departement
Department of Pathology
Head
Prof. Marin Ts. Alexandrov, DVM. PhD
Tutor
Assoc. Prof. Radostina Alexandrova, PhD (Permanent position in IEMPAM ? BAS; Part time Ass
Languages
English, Russian, Spanish
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
No No No No No Yes Yes No No Yes No No
Type of Research Project
- Basic science
What is the background of the project?
Bone loss due to trauma or disease is an increasingly serious health problem. It has been predicted that the percentage of persons over 50 years of age affected by bone diseases will double by 2020 (1). Bone and joint degenerative and inflammatory problems, bone fractures, low back pain, osteoporosis, scoliosis ant other musculoskeletal problems need to be solved by using permanent, temporary or biodegradable devices devices (2-3).

Calcium phosphate bioactive materials (ceramics, cements) have been used in the medicine and dentistry due to their chemical and structural resemblance to bone tissue mineral composition. They induce a biological response similar to the one generated during bone remodeling. During resorption, the degradation products of calcium phosphate bioceramics (calcium and phosphate ions) are naturally metabolized and they do not induce abnormal calcium or phosphate levels in urine, serum, or organs.

The ion-modified calcium phosphates possess some specific biologically important characteristics. Thus, Mg is among the preferable modifiers as it is an essential trace element for the organisms. Magnesium is closely associated with mineralization of calcified tissues, and indirectly influences mineral metabolism (4). Mg and Zn modified tricalcium phosphate ceramics were found to exhibit lower solubility than the pure ones (5-6) and hence reduce the resorption rate (7).
What is the aim of the project?
To investigate on the biocompatibility of modified calcium phosphates and composite materials for bone implants
What techniques and methods are used?
1.Cement production 2 Model selection 3 Surgery 4 Sacrifice and sample collection 5 Histological analysis 6 Statistical analysis
What is the role of the student?
- The student will mainly observe
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
The student will assist in the examination of the data compiled.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes please contact your LORE
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
- The student will prepare a presentation
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
No special skills and knowledge are required ? the education (first and second year) in Medical and Biological faculties is completely enough.
No legal limitations exist.
For the use of students considering participating in the project, further information can be found from the following articles:

1. Boyka Andonova-Lilova, Radostina Alexandrova, Diana Rabadjieva_, Stefka Tepavitcharova_ APPLICATION OF CULTURED MURINE CELLS FOR INITIAL EVALUATION OF THE BIOCOMPATIBILITY OF Mg AND Zn-MODIFIED TRI-CALCIUM PHOSPHATES. Comptes rendus de l
Are there any legal limitations in the student’s involvement
No
Hours
7
Type of students accepted
This project accepts:
- Medical students
Articles
- 1. Boyka Andonova-Lilova; Radostina Alexandrova; Diana Rabadjieva_; Stefka Tepavitcharova_ APPLICATION OF CULTURED MURINE CELLS FOR INITIAL EVALUATION OF THE BIOCOMPATIBILITY OF Mg AND Zn-MODIFIED TRI-CALCIUM PHOSPHATES. Comptes rendus de l