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Cellular and molecular mechanisms of skeletal muscle plasticity
Universita degli Studi di Pavia
Dipartimento di Fisiologia, Via Forlanini 6, 27100 Pavia, Italy
Prof. Roberto Bottinelli firstname.lastname@example.org +39.0382.987257
Roberto Bottinelli, Monica Canepari, Maria Antonietta Pellegrino, Giuseppe D
Type of Research Project
- Basic science
What is the background of the project?
Skeletal muscles are used for a wide variety of motor tasks ranging from maintaining posture to whistling, from jumping to breathing, from running at ~40 Km/h for 10 s (100 metres) to running at half the speed for ~2h (i.e. the marathon, 42.195 Km). The capacity to accomplish such variable motor tasks relies on the very fine motor control performed by the nervous system and on the very large functional heterogeneity and plasticity of skeletal muscles. The nervous system can finely tune the performance of a given muscle adapting its power output to the motor task on a very short time base, milliseconds/seconds (phasic control). Skeletal muscles can adapt their contractile properties to the requirements of their predominant motor tasks by changing their structure on a long time base, weeks-months (tonic control). The project focuses on the large functional variability and plasticity of skeletal muscle and aims to identify the underlying mechanisms. It is now widely accepted that the existence of isoforms of myosin, the motor of contraction, is a major determinant of such large variability. However, the mechanisms underlying myosin isoforms diversity are far from being fully understood and will be the focus of the present project.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
The student will learn to perform basic muscle physiology experiments in vitro. The student will learn the most updated hypotheses of how skeletal muscle can vary its performance and adjust to the requirements of movement and locomotion. The student will learn the basic techniques to study the function of muscle and myosin function in vitro and to separate and identify myosin isoforms.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Original research papers will be provided to the student to understand the background of the project.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student should have a background of cell biology and biochemistry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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