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(Santiago de Chile) Congenital Chagas disease: mechanism of Trypansosoma cruzi infection and invasion in human placenta.
Universidad de Chile
Anatomy and Developmental Biology
Dr. Antonio Morello
Dra. Ulrike Kemmerling
English, Spanish, German
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The congenital Chagas disease is cause by Trypanosoma cruzi transmission from an infected mother to her child during pregnancy. The incidence is low and varies depending on the region of America. This infection can present with symptoms or not, which means that sometimes their development doesn´t have external signs.
What is the aim of the project?
Study in an ex vivo infection model of the human chorionic villus tissue the possible alterations, cellular and biochemical characteristics of the disease.
What techniques and methods are used?
Histochemestry, immunohistochemestry, molecular biology (PCR, TUNEL) and Western blot.biology technics
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
What are the tasks expected to be accomplished by the student?
Participate in the project during the exchange time
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student’s name will be mentioned in a future publication - The student will have the opportunity to present the results together with the supervisor at a conference
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student needs special knowledge about cell biology, molecular biology, histology and biochemistry.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months) - Students in biomedical fields
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