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Role of intestinal bacteria in the development of mucosal inflammation observed during inflammatiory bowel diseases (Crohn
France (ANEMF) - University of Auvergne, Clermont-Ferrand
Pathogenie Bacterienne Intestinale, JE2526, Universite d
Pr Arlette Darfeuille-Michaud
Barnich, Elisabeth Billard, Mathilde Bonnet, Marie-Agnes Bringer
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn
What is the aim of the project?
To understand the role of intestinal bacteria in the development of mucosal inflammation observed during inflammatiory bowel diseases (Crohn)
What techniques and methods are used?
Clinical : examination of patients and data analysis.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Molecular and cellular activities under supervision of the tutor
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
A skill in molecular and cellular biology is welcome. For the use of students considering participating in the project, further information can be found from the following articles:
Barnich, N., et al., CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest, 2007. 117(6): p. 1566-74.
Darfeuille-Michaud, A., et al., High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology, 2004. 127(2): p. 412-21.
Lapaquette, P., et al., Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol. 12(1): p. 99-113.
Rolhion, N., et al., Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion. Gut 2010
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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