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Breast cancer phenotype in a population of women with BRCA1/BRCA2 hereditary breast cancer followed in the Cancer Center of Montpellier
France (ANEMF) - University of Montpellier, Montpellier
Department of oncogenetic and Laboratory of Biology - CHU Arnaud de Villeneuve
Pr T. Maudelonde, Pr P. Pujol
Drs I. COUPIER and N. BOULLE
Type of Research Project
- Clinical Project without Laboratory work
What is the background of the project?
About 10% of all breast cancers arise from hereditary cause ; 60% to 75% of these cancers are caused by contitutional mutations in the BRCA1 or BRCA2 genes (Antoniou A et al, 2003 Am J Hum Genet ; Ford D et al, 1998 Am J Hum Genet). The phenotype of BRCA1 associated breast cancers are more basal like carcinoma than BRCA2 or sporadic breast cancer. It is reasonable to speculate that in the futur, the treatment of hereditary breast cancer will be condordant with these specific histological and molecular phenotypes.
The aim of the project is to describe and analyse the phenotype of breast cancers in a population of women with BRCA1/BRCA2 mutated breast carcinoma followed by Dr I. Coupier in the Centre Regional de Lutte Contre le Cancer (CRLCC Val d'Aurelle) of Montpellier.
This is a retrospective project analysing both clinical and biological data collected from the follow-up of women with BRCA mutated breast carcinoma. In addition to collecting clinical and pathological data, the student will be teached in the laboratory about the molecular approaches used to detect BRCA1/2 mutations from blood samples.
The role of the student will be to collect data from the population of women selected for this study, to list them properly using appropriate softwares so they can be used for future studies and to compare them with data from the literature. The data to be collected will be previously discussed with the tutors.
Student's outcome : at least oral presentation in front of medical and technical staff.
The student will acquire knowledge about breast cancer in general and hereditary breast cancer in particular, knowledge about the molecular approaches used for diagnosis of hereditary cancer and more generally detection of DNA mutations.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
For the use of students considering participating in the project, further information can be found from the following articles:
- Germline BRCA1 mutations and a basal epithelial phenotype in breast carcinoma. Foulkes W. et al. 2003 J National Cancer Inst 95: 1482.
- Basal-like breast cancer: from molecular profiles to targeted therapies. Toft D.J. and Cryns V. L.2010 Molecular Endocrinology First published ahead of print September 22, 2010.
- Identification of basal-like carcinomas in clinical practice: "triple zero/BRCA1-like carcinomas" Vincent-Salomon A. et al. 2010 Bulletin du Cancer 97: 357 (french)
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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