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Animal models of human retinal degeneration: structure function correlations.
Visual Electrophysiology Laboratory and Clinic, Montreal Children
Dr Pierre Lachapelle
Dr Pierre Lachapelle
English required, French accepted
Type of Research Project
- Basic science
What is the background of the project?
What is the aim of the project?
The purpose of this study is to develop animal models of human retinopathies such as retinopathy of prematurity or age related macular degeneration for example.
What techniques and methods are used?
The techniques used to assess the models are: electroretinography, retinal histology, immunohistochemistry and western blot to name a few.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Acquire the knowledge, participate in writing of protocol (including hypothesis) do the experiments, analyze the data and if everything works according to plan, present data to meetings and write a paper. The student will also be asked to actively participate at weekly journal clubs.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Please read <br> <br>JOLY, S., PERNET, V., CHEMTOB, S., Di POLO, A., LACHAPELLE, P. Neuroprotection in the juvenile rat model of light-induced retinopathy : Evidence suggesting a role for FGF-2 and CNTF. Investigative Ophthalmology and Visual Science. 48: 2311-2320, 2007. <br> <br>DORFMAN, AL, POLOSA A, JOLY S, CHEMTOB S, LACHAPELLE P. Functional and structural changes resulting from strain differences in the rat model of OIR. Investigative Ophthalmology and Visual Science. 50: 2436-2450, 2009.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student will have the opportunity to present the results together with the supervisor at a conference - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Willing to do the work is the most important skill required! The rest will come with the onsite training.
Are there any legal limitations in the student’s involvement
No legal limitations as long as the student accepts to go through the animal certification process.
Type of students accepted
This project accepts: - Medical students
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