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Betablocking agents or corticosteroids: two potential treatments in response to inflammation during sepsis?
France (ANEMF) - University of Versailles, Versailles
Neuroendocrine response to sepsis laboratory (EA 4342)
Professor Djillali ANNANE
Arnaud MANSART (PhD, lecturer)
Type of Research Project
- Basic science
What is the background of the project?
Since 1994, we have studied the neural endocrine response to sepsis following three different approaches: 1) analysis of activation of the Hypothalamic-Pituitary-Adrenal axis, 2) analysis the noradrenergic control of the cardiovascular homeostasis and 3) of the regulation of vasopressin synthesis.
To improve our knowledge on two different potential treatments (Betablocking agents and corticosteroids) during sepsis.
The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an interesting new therapeutic target for septic shock. Beta1 blockade seems to reduce sepsis-induced immune, cardiovascular, coagulation dysfunctions and improves survival.
Corticosteroid therapy has been used in varied doses for sepsis and related syndromes for more than 50 years, with no clear benefit. Since 1998, studies using low-dose corticosteroid therapy, suggests a beneficial drug effect but these effects remains controversal.
Techniques and Methods:
Hemodynamic studies / Survival / DNA Microarray / Western Blot / Elisa
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic practical skills (e.g., pipetting) and knowledge on pharmacology are desired.There are no legal limitatons
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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