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Role of retinoids (active derivatives of retinol) in the physiopathology of the human amniotic membranes.
France (ANEMF) - University of Auvergne, Clermont-Ferrand
Dr. Chantal Vaury
Pr. Vincent Sapin
French and English only
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
molecule for the mammalian species (embryonic development). Strong evidence
indicates that these retinoids are also important for a harmonious development of
the extra-embryonic structures: placenta and the amniotic membranes. The aim
of our project was to determine how the retinoids regulate the physiology of the
human amniotic membranes and if the retinoids could be used as therapeutics
tools for pathologies of these fetal membranes, as iatrogenic preterm rupture of
membranes. The project is based on classical molecular biology assays and cells
culture to study the regulation of target genes by retinoids in human amniotic
Preliminary readings: review with key words: human amniotic membranes / retinoids and publications of the group talking about retinoids and placental /amniotic membranes.
The student is expected to manipulate cells line, to incubate these cells with retinoids, and to extract RNA and proteins to determine the various expression levels. He/She could be implicated in bioinformatic strategy. The student will be associated to the posters, communications or papers that will be using her/his data.
You will acquire:
Strong knowledge regarding developmental implications of retinoids, amniotic membranes biology, and assays concerning metabolic and molecular aspects of the retinoids.
~ MARCEAU G., GALLOT D., LEMERY D., SAPIN V. (2007) Metabolism of retinol during mammalian placental and embryonic development. Vitamin and Hormons 75: 97-115. [IF: 3.889].
~ BOREL V., MARCEAU G., GALLOT D., BLANCHON L., SAPIN V. (2009) Retinoids regulate human amniotic tissue-type plasminogen activator gene by a two-step mechanism. J. Cell. Mol. Medecine: sous presse. [IF: 6.807]
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will mainly observe
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
A skill in basic molecular biology and cell culture is needed.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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