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Inflammatory response; the cause or consequence of premature rupture of maternal envelopes?
Czech Republic (IFMSA CZ) - Charles University in Hradec Kralove, Hradec Kralove
Department of Clinical Immunology, Charles University in Prague, Hradec Kralove
Prof. Jan Krejsek, Ph.D.
Ondrej Soucek, MSc.
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
There are different reasons of premature rupture of maternal envelopes with very different clinical consequences. The most frequent reason is immunopathological inflammatory response induced either by infectious stimuli or by DAMP release. This inflammation is addressed by our long term scientific effort which is based on the detection of various biomarkers in amniotic fluid and cord blood by immunoassays and flow cytometry.
What is the aim of the project?
To better understand to the pathophysiology of maternal envelope rupture.
What techniques and methods are used?
Flow cytometry, immunochemistry, ELISA, Luminex.
What is the role of the student?
- The student will mainly observe
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
To get acquainted with the subject thoroughly and to participate fully in the research and the team work in the lab.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
There will be articles provided to better understand the subject.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of immunology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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