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Diagnostic tests for celiac disease
Greece (HelMSIC) - University of Ioannina, Ioannina
Child Health Department, Research Laboratory, Medical School, University of Ioannina
Nikolaos Chaliasos , Associate professor
Anna Challa, PhD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Background Information: Celiac disease is a malabsorptive disorder resulting from intolerance to gluten and leads to systemic problems due to nutritional deficiencies. The incidence of celiac disease is underestimated. It is believed that only 1 in 7 is diagnosed. Also, in subjects with IgA deficiency the incidence is 10 times higher than in the general population. What is the aim of the project? In order to screen children who attend the hospital's pediatric clinic or are admitted into the pediatric wards, for several reasons and investigate the incidence of celiac disease in the pediatric population of Greece. What techniques and methods will be used? Enzyme immunoassays and Immunohistochemistry for antigliadin antibodies IgA & IgG, anti-endomysium antibodies and anti-t-transglutaminase antibodies.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- If the project includes “lab work”
- the student will take active part in the practical aspect of the project
- If the project is clinical
- the student will take active part in the clinical examination
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Lab Work and data analysis
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Yes if needed.
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
What skills are required? Is there any special knowledge or certain level of studies needed?
To be interested in laboratory work.
The student should have a very good command of English language.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Molecular basis of celiac disease. Ludvig M. Sollid
- Annu. Rev. Immunol. 2000; 18: 53?81
- Celiac Disease: An Immunological Jigsaw. Bertrand Meresse
- Georgia Malamut and Nadine Cerf-Bensussan. Immunity 2012; 36: 907-919
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