What is the background of the project?
What is the aim of the project? What kind of techniques and methods will be used?
We propose precise projects according to the profile of the students who are candidate. at this stage, as our team is multidisciplinary we describe the general project of the team and according to the students we can target one or the other aspects, also according to the period and who is theer for supervising at that time..
The team addresses the implications of genomics for public health, especially issues pertaining to biobanks and to multifactorial diseases. It brings together competencies in medicine, biology, rheumatology, human genetics, immunogenetics, population analyses and genetic epidemiology, public health, health economics, health products assessment, health law, sociology of sciences and of health, health psychology and bioethics. It concentrates on ethical and societal challenges and on statistical methods in genetics. The approach is anchored in a reflection on the organizational, societal and medical stakes of the analyses of genetic diversity in population, those of the constitution and the use of biobanks and genetic data, at the regional, national and international level and those of the development of biotherapies, e.g. cell therapies. Three objectives are targeted: 1) studying how to take into account genetic diversity to optimize preventive measures and to reduce inequalities; 2) modeling steps and scenarios to implement new genomics parameters or innovative therapies into the health sector and existing organisations; 3) analysing new dimensions of the information provided to/by health professionals or lay people, its modalities and its consequences. Researches are based on a common multidisciplinary setting allowing the analysis of the context and the outcome of genomics research for health. Two practical domains are addressed, with international collaborations:-transplantation, especially a) optimising haematopoietic stem cells donor Registries or cord blood banks at qualitative, quantitative and economical levels, in order to better match the patients needs; and b) the validation and use of biomarkers of tolerance and tolerance induction protocols using cell therapies -use of genetic epidemiology data in patient care and analysing their implications in patient/doctor/family interactions, with rheumatoid arthritis as a model.
Depending on the period. Not between July and September
Participating in the research work with usually a report at the end; sometimes it can be participation to a more general report or publication.
You will acquire:
Genetic epidemiology analyses; bibliography and analyses of articles in English and French; more generally an openness on multidisciplinary work. Methodology of various kinds of surveys.
1: Kauffmann F, Cambon-Thomsen A.
Tracing biological collections: between books and clinical trials.
JAMA. 2008 May 21;299(19):2316-8. No abstract available.
2: Barnetche T, Constantin A, Cantagrel A, Cambon-Thomsen A, Gourraud PA.
New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a
combined analysis of worldwide samples.
Arthritis Res Ther. 2008;10(1):R26. Epub 2008 Feb 28.
3: Cambon-Thomsen A, Rial-Sebbag E, Knoppers BM.
Trends in ethical and legal frameworks for the use of human biobanks.
Eur Respir J. 2007 Aug;30(2):373-82.
4: Juillard-Condat B, Constantin A, Cambon-Thomsen A, Bourrel R, Taboulet F.
Impact of etanercept on the costs of rheumatoid arthritis (RA): results from a
French observational study.
Joint Bone Spine. 2008 Jan;75(1):25-8. Epub 2007 Aug 27.
5: Feve F, Cambon-Thomsen A, Eliaou JF, Gourraud PA, Raffoux C, Florens JP.
[Economic evaluation of the organization of a registry of haematopoietic stem
Rev Epidemiol Sante Publique. 2007 Aug;55(4):275-84. French.
... and many more upon request !
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Knowing preferably French; be interested in ethical and legal aspects of transplantation and/or genetics; some level of statistical analyses and computer skills for analysing genetic data appreciated