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Signal transduction of the Neural Cell Adhesion Molecule
Germany (bvmd) - Martin-Luther-Universitaet Halle-Wittenberg, Halle a.d.Saale
Institute for Physiological Chemistry, Martin-Luther-University, Hollystr. 1,D-06114 Halle
Prof. Dr. Ruediger Horstkorte
Dr. Kaya Bork, Dr. Wenke Weidemann
Fluent English or German
Type of Research Project
- Basic science
What is the background of the project?
The neural cell adhesion molecule NCAM represents an adhesion receptor of the immunoglobulin superfamily and is expressed in three major isoforms. These isoforms differ only in their cytoplasmic domains and are designated by their molecular weight. NCAM120 has no transmembrane domain, whereas NCAM140 and NCAM180 exhibit differential cytoplasmic domains. Beside of cell adhesion, NCAM is also involved in neurite outgrowth, cell migration and cell differentation. Even after two decades of research, little is known on the function of NCAMs cytoplasmic domains. Only recently the fundamental signal transduction pathways of NCAM have been described. In previous studies we could identify several novel intracellular binding proteins of NCAM. In the future, we plan to study the following topics: -phosphorylation of NCAM and neurite outgrowth (axonal growth) -analysis of the function of ncam-interacting molecules LANP, TOAD and rok-alpha during NCAM-mediated signaltransduction or neurite ougrowth -analysis of the biological stability of ncam after homophilic NCAM-stimulation There will be lab Meetings and intensive training by the personal supervisor.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge in biology, biochemistry or chemistry. There are no limits in the involvement.
FLUENT English is absolutely necessary!
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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