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Elucidation of the mechanisms underlying the induction of astrogliosis by Angiotensin II
Université de Montréal
Department de pharmacologie, Faculty of Medicine, University of Montreal
Dr Patrick du Souich
Dr Helene Girouard
English required, French and Spanish are accepted
Type of Research Project
- Basic science
What is the background of the project?
Study 1: To determine whether Angiotensin II (7 days treatment) induces astrogliosis. The volume of astrocytes will be determined by measuring the increase in GFAP production (immunohistochemistry, western blot) as well as the increase of astrocytic volume (confocal microscopy and stereology). The control model will be the phenylephrine model which increases arterial pressure without increasing free radical production.
Study 2: To determine whether induction of astrogliosis by Angiotensin II can be blocked by AT1 antagonists as well as antioxidant treatments.
What is the aim of the project?
These studies will help to define therapeutical targets to prevent dementia and cognitive dysfunctions associated to astrogliosis.
What techniques and methods are used?
What is the role of the student?
- The tasks of the student will be performed on his/her own
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
The student will be expected to be responsible of the project. The student will be expected to participate to the development of the protocols as well as to perform molecular biology and immunochemistry experiments. The student will also have to perform minor surgeries, monitor the arterial blood pressure and learn confocal microscopy. Consequently, the student will have to study the literature in the subject and to think about the best experimental conditions to accomplish these studies. The student will be expected to actively participate to the weekly meetings where we will discuss about technical problems, ways to improve protocols, possible new hypothesis and interpret our results. The student will be expected to analysis his results and to present them to the lab meetings. The student will acquire technical skills in molecular biology, immunostaining, blood pressure monitoring, surgery and confocal microscopy. The student will also learn how to conduct a project from the elaboration of the protocol to the presentation of the results. Through this experience the student will develop rigor, precision, analytical skills as well as communication skills.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - The student will prepare a scientific report - The student will prepare an abstract - The student’s name will be mentioned in a future publication - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student will be required to have some experience in a laboratory: know how to use a pipette and some basic knowledge in chemistry and molecular biology
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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