Projects
Name
Genetic Predisposition to Complex Diseases: Cancer, Autoimmunity and Infectious Diseases
University
Universidade Federal do Para (UFPA)
Domain
Genetics
Departement
Federal University of Para, Laboratory of Human and Medical Genetics of CCB - UFP
Head
Eduardo Jose Melo dos Santos, PhD, MSc
Tutor
Eduardo Jose Melo dos Santos, PhD, MSc
Languages
Portuguese, English and Germany
Duration
4 weeks
Availability
Cities/Months Jan Feb Mar Apr May Jun Jul Augt Sep Oct Nov Dec
Yes Yes Yes Yes Yes Yes No Yes Yes Yes Yes Yes
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The current project approaches genetic predisposition to many complex diseases, by using, mainly genotyping of immunorelevant genes in case/control studies. Laboratorial analysis involving molecular genetics methods and statistical treatment of the data will be issues of the training of the students.
What is the aim of the project?
The project aims to investigate predisposing genes to complex diseases like cancer, autoimmune conditions [rheumatoid arthritis, systemic lupus], and infectious diseases [dengue fever, hepatitis B and C, AIDS, tuberculosis, and leprosy]
What techniques and methods are used?
DNA isolation; electrophoresis; case-control sample designing; PCR; DNA sequencing; real time quantitative PCR and statistical approaches in case control studies.
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Development of laboratorial skill in molecular biology and statistical analysis.
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
No
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
It's necessary to have knowledge about immunology
Are there any legal limitations in the student’s involvement
No
Hours
5
Type of students accepted
This project accepts:
- Medical students
- Students in biomedical fields
Articles
- • Expression of PLIN2 and PLIN3 during oocyte maturation and early embryo development in cattle. Theriogenology ; v. 81; p. 326-331; 2014 ;
- • Association of killer cell immunoglobulin-like receptor polymorphisms with chronic hepatitis C and responses to therapy in Brazil. Genetics and Molecular Biology (Impresso) ; v. 36; p. 022-027; 2013 ;
- • A database for curating the associations between killer cell immunoglobulin-like receptors and diseases in worldwide populations. DATABASE-OXFORD ; v. 2013; p. bat021-bat021; 2013 ;
- • Descriptive study of HTLV infection in a population of pregnant women from the state of Pará; Northern Brazil.. Revista da Sociedade Brasileira de Medicina Tropical (Impresso) ; v. 45; p. pii: S0037-868; 2012 ;
- • Beta-globin polymorphisms in Amerindian populations from the Brazilian Amazon. American Journal of Human Biology ; v. 24; p. 432-435; 2012.