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Role of toxins in the virulence of Escherichia coli
France (ANEMF) - University of Toulouse, Toulouse
Jean-Philippe Nougayrede, Frederic Taieb
French and English only
Type of Research Project
- Basic science
What is the background of the project?
Description of the project :
Escherichia coli belong to the initial microflora colonizing the gut of humans and most warm-blooded animals. However, E. coli is also a highly versatile bacterial species with considerable pathogenic potential. E. coli is one of the most frequent causes of bacterial infections, including, bacteremia, urinary tract infections, diarrhea, and other clinical infections such as neonatal meningitis, hemorrhagic colitis or hemolytic uremic syndrome. E. coli infection is a significant public health problem worldwide; 10 to 20 percent of women have had at least one episode of cystitis due to E. coli in their lifetime, and 80 percent of this group has had it recurrently. E. coli causes 10-50% of nosocomial infections. E. coli is also an emerging foodborne pathogen which is now recognized as the most common cause of life-threatening acute kidney failure in childs. In developing countries, E. coli is a leading cause for infant acute diarrhea and the primary cause of travellers' diarrhea. These clinical manifestations are due to the virulence factors of specific E coli pathotypes : extracellular pathogenic E. coli (ExPEC), enterohemorrhagic E coli (EHEC), enteropathogenic E coli (EPEC), enterotoxigenic E. coli (ETEC)
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Classes in microbiology and immunology (mandatory)
Previous Research experience in a laboratory (optional), enthusiasm, curiosity, and a real interest for research in basic biomedical sciences
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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