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Role of ACPA on Rheumatoide Arthritis
France (ANEMF) - University of Toulouse, Toulouse
CNRS University of Toulouse III UMR5165 , CHU Purpan
Dr M.SEBBAG, Dr L.NOGUEIRA
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Autoantibodies to citrullinated proteins (ACPA)are tightly associated to Rheumatoid Arthritis (RA) and recognise peptidic epitopes generated by citrullination of arginyl residues, mediated by a peptidylarginine deiminase (PAD). They are secreted by plasma cells of the synovial tissue (ST) where their major target correspond to citrullinated fibrin. In the recent years, we identified 3 minimal epitopes of citrullinated fibrin entirely encompassing the reactivity of ACPA to fibrin. We also proposed that the autoimmune reaction between fibrin and ACPA plays the major role in the persistence of synovial tissu inflammation and developed an in vitro model that allowed demonstrating the capacity of immune complexes (IC) between citrullinated fibrin and ACPA to induce TNF alpha secretion by macrophages.
techniques and methods used : ELISA, cell sorting, cell culture, protein chromatography, cytometrie
The student will have to observe, understand and reproduce
During the exchange program, the student will see the first approach of fundamental and bioclinical research programs and methodologies understanding of autoimmunity.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
At least 3rd year of medical training
If the student wants to be involved in some of the less precious experiments performed during the stay, he/she will have to have had some previous technical training on the basics (pipetting, making a solution, adjusting pH, weighing, sterile manipulation etc).
They are expected to conform with the time schedules of the experiment they are being shown. If they are interested they can take notes and learn how to make experimental reports.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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