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Oxidative stress in elderly : involvement of NADPH oxidase system
France (ANEMF) - University of Montpellier, Montpellier
Biochemistry departement, Hopital Lapeyronie, 371 Avenue du Doyen Gaston Giraud
Cristol JP, MD-PhD, Biochemistry, G. Baptista, MDMsc, AM Dupuy, MD-PhD
French and English only
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
Oxidative stress has been largely involved in ageing. This umballance between reactive oxygen species (ROS) and defense mechanisms could result either from an overproduction of reactive species or an impairment of antioxidant systems such as vitamins and polyphenols or enzymatic systems such as superoxide dismutase , gluthatione peroxidase or catalase. The NADPH oxidase system is now recognized as a key enzyme in ROS production which is closely linked to inflammation. In a prospective cohort of 800 elderly patients (>65 yo) we have shown that ROS production in whole blood increases with age and that in multivariate analysis inflammation and homocystein leels are the main detrminants of ROS production. In addition, ROS production is clearly associated with the fraility index.
Aim of the project:
To test the hypothesis that micronutriments such as polyphenols (given as a glass of wine) or superoxyde enzyme (given as a vegetable extract) could modulate ROS production
Techniques and methods:
Superoxide production in whole blood using chemiluminescence
Clinical data collection
Preliminary readings, previous works of the team in the field of oxidative stress specially in elderly
Seminars of the team
Understanding of the experiments
Data collection and first steps of interpretation
Outcome of your participation:
Redaction of a memory, eventually participation to a poster
You will acquire:
Learning the requirements for a bioclinical project, understanding of oxidative stress concept, laboratory technical practise and clinical data management, initiation of data interpretation
Ventura E, Durant R, Jaussent A, Picot MC, Morena M, Badiou S, Dupuy AM, Jeandel C, Cristol JP. Homocysteine and inflammation as main determinants of oxidative stress in the elderly. Free Radic Biol Med. 2009 Mar 15;46(6):737-44.
Scapagnini G, Bulati M, Candore G, Castiglia L, Colonna-Romano G, Lio D, Nuzzo D, Pellicano M, Rizzo C. Biomarkes of aging. Front Biosci (Schol Ed). 2010 Jan 1;2:392-402.
De la Fuente M, Miquel J. An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des. 2009;15(26):3003-26.
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The student will mainly observe
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge of physiopathology.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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