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Metabolism of membrane sphingolipids during inflammation and sepsis
Germany (bvmd) - Friedrich-Schiller-Universitaet, Jena
Dept. for Anaesthesiology and Intensive Care Therapy
Prof. Dr. K. Reinhart
Dr. Ralf A. Claus, Ph.D., E-mail:
, ++49 (0) 3641 9325860
Fluent English, German
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The hydrolytic activity of the plasma secreted isoform of the lysosomal sphingomyelinase SMPD1 is enhanced in patients with systemic inflammatory response such as sepsis and cardiac heart failure. However, there are no data on the source, secreting mechanisms and the impact on the generalisation in the course of host response. Therefore, we intend to analyze in a translational procedure cellular mechanisms for its regulation in inflammation relevant systems such as functional active human liver slices and cell culture models. Furthermore we aim to monitor in animal experiments the kinetic and dynamic of the inflammation-mediated release, the potential impact for microcirculation as well as beneficial effects of a specific inhibition. Also, in patients with uncomplicated community acquired pneumonia, severe sepsis as a result of pneumonia and severe sepsis in the course of peritoneal infection its potential impact for the progression of the disease from colocalisation to systemic infection, the development of organ failure and patients.
What is the aim of the project?
To further describe the role of secreted sphingomyelinase in inflammation and to define a potential role as therapeutical target.
What techniques and methods are used?
Techniques: immunopraecipitation, western blotting, activity assays, immunohistochemistry.
What is the role of the student?
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
Courses and seminars
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Interest in the field of inflammation and cellular stress response FLUENT English is absolutely necessary!
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students
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