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Genetics of microvascular complications in type 2 diabetes
Slovenia (SloMSIC) - University of Ljubljana, Ljubljana
University Ljubljana, Medical faculty, Institute of histology and embryology
prof. dr. Daniel Petrovič, dr. med.
Professor Daniel Petrovic, MD, PhD
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
In Slovenia there are more then 125.000 people with diabetes and the number is still rising. 22,2% of population over 75 years old has type 2 diabetes and 16% of those between 65 and 75. Diabetes is associated with both microvascular and macrovascular diseases affecting several organs, including muscle, skin, heart, brain, and kidneys. This disorders are also the leading cause of visual loss, end-stage renal disease and amputation. One of the important risk factors for developing all this complications in diabetes is also genetics. This project will focus on finding the link between different gene polymorphisms and the rate of micro- and macrovascular complications in older patients with diabetes type 2.
What is the aim of the project?
The aim is to find genetic markers of microvascular complications in type 2 diabetes.
What techniques and methods are used?
Genetical analysis will be performed (Real-time (RT) – Polymerase chain reaction (PCR), restriction fragment length polymorphism, gel electrophoresis, DNA isolation) to evaluate genetic polymorphisms and define risk genotypes as potential genetic markers.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Student will participate in lab work. He/she may also participate in poster/paper (depending on the interest and preliminary knowledge).
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster - The student will prepare a presentation - No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Basic knowledge regarding the PCR (polymerase chain reaction) analysis is helpful, but not necessary.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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