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The biology and treatment of Chronic Myeloid Leukemia and prognostic value of Minimal Residual Disease.
Hungary(HuMSIRC)- University of Szeged,Szeged
Medical Genetic Department, 6720_Somogyi B.st.4 Szeged Hungary
Prof. Dr. Szab
Type of Research Project
- Clinical Project with Laboratory work
What is the background of the project?
The introduction in 1998 of imatinib mesylate (IM) revolutionized management of patients with chronic myeloid leukemia (CML) and the second generation of tyrosine kinase inhibitors may prove superior to IM. Real-time quantitative polymerase chain reaction (RQ-PCR) provides an accurate measure of the total leukemiacell mass and the degree to which BCR-ABL transcripts are reduced by therapy correlates with progression-free survival. Because a rising level of BCR-ABL is an early indication of loss of response and thus the need to reassess therapeutic strategy, regular molecular monitoring of individual patients is clearly desirable. The aim of the project is to use serial RQ-PCR results rather than bone marrow cytogenetics or fluorescence in situ hybridization (FISH) for the BCR-ABL gene to monitor individual patients responding to treatment.
What is the aim of the project?
The aim of the project is to use serial RQ-PCR results rather than bone marrow cytogenetics or fluorescence in situ hybridization (FISH) for the BCR-ABL gene to monitor individual patients responding to treatment.
What techniques and methods are used?
cytogenetics, fluorescence in situ hybridization (FISH)
What is the role of the student?
- The student will observe the practical experiments but will be highly involved in the analysis of the results
What are the tasks expected to be accomplished by the student?
basic lab work
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- The student will prepare a poster
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Advanced genetic technical knowledge can be obtained.
Human genetics and molecular biology studies
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
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