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The molecular mechanisms of ornithine decarboxylase (ODC)-prevented apoptosis in the early events
Taiwan (FMS-Taiwan) - Chung Shan Medical University, Taichung
Chung-Shan Medical University, Institute of Immunology, R.1004, NO.110, sec.1, Chien-Kuo N
Type of Research Project
- Basic science
What is the background of the project?
Our hypothesis is that ODC and polyamines could regulate the earlier upstream events of caspase 8 activation, such as lipid rafts and DISC formation to inhibit the extrinsic death pathway. Therefore, we aim to accomplish the following studies to elucidate the molecular mechanisms of ODC-prevented apoptosis in the early events. 1. The roles of ODC in early events of TNFα-induced apoptosis 2. The roles of ODC in the spontaneous apoptosis and caspase-independent cell death of neutrophils
What is the aim of the project?
This aim of the project is to find out how ornithine decarboxylase(ODC) prevented apoptosis in early events.
What techniques and methods are used?
The techniques and methods used in the project：Cell culture, Western blotting, RT-PCR, Immunoblotting, Immunoprecipitation, Immunofluorescence microscopy, Kinase activation assays.
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
The student needed to know the basic knowledge concerning about Cell Biology, Biochemistry, Immunology and Molecular Biology.
There is no legal limitations in this project.
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Graduated students (less than 6 months)
- Antizyme; a natural ornithine decarboxylase inhibitor; induces apoptosis of haematopoietic cells through mitochondrial membrane depolarization and caspases
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