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Effect of oxygen on vascular function in wellness and illness
Croatia (CroMSIC) - Josip Juraj Strossmayer University of Osijek, Osijek
Clinical Hospital Osijek
Ines Drenjancevic MD, PhD
Sanja Novak, Anita Cosic, Zrinka Mihaljevic, Martina Mihalj
Type of Research Project
- Basic science
What is the background of the project?
Adequate peripheral tissue perfusion primarily depends on ability of resistant blood vessels to increase or decrease diameter in response to various vasodilator and vasoconstrictor stimuli. Previous studies demonstrated that in diabetes mellitus there is an enhanced vasoconstriction and impaired vasodilation in response to different stimuli, which could be one of the risk factors for development of microangiopathy, impaired regulation of blood flow in peripheral tissues and development of tissue hypoxia and ischemia. Hyperbaric oxygen therapy (HBOT) is an adjuvant therapy for some ischemic conditions in diabetic patients, but controversial in therapy of cerebral ischemia. Although physiological mechanisms of HBOT are not fully understood, some studies showed that HBOT could alter expression various enzymes (such as COX-2 and eNOS) both in brain tissue and in endothelial cell culture thus possibly affecting vascular structure and function. The general purpose of this project is to evaluate the effects of HBOT on vascular reactivity and blood vessel structure in normal rats and in rats with streptozocin-diabetes mellitus. This project will test hypothesis that HBOT will affect normal and impaired vascular control mechanisms of cerebral resistant vessels in response to vasodilator and vasoconstrictor stimuli and will affect cerebral blood flow regulation via HBOT affecting enzymes in various pathways mediating vascular reactivity to vasodilator and vasoconstrictor stimuli. In contrast to HBOT, chronic intermittent hypoxia (CIH) will compromise CBF regulation due to effect of CIH to impair vascular responses to endothelium dependant stimuli.
In the evaluation of the blood vessels function we will use in vitro videomicroscopy of isolated, perfused resistant vessels, aortic ring studies, in vivo laser Doppler flowmetry, biochemical measurement of vasoconstrictor and vasodilator mediators and determination of the protein expression (eNOS, COX-1,2, CYP450 omega-hydroxyl
What is the aim of the project?
What techniques and methods are used?
What is the role of the student?
- The tasks will be done under supervision
What are the tasks expected to be accomplished by the student?
Will there be any theoretical teaching provided (preliminary readings, lectures, courses, seminars etc)
What is expected from the student at the end of the research exchange? What will be the general outcome of the student?
- No specific outcome is expected
What skills are required of the student? Is there any special knowledge or a certain level of studies needed?
Bring your own white coat!
Are there any legal limitations in the student’s involvement
Type of students accepted
This project accepts: - Medical students - Pre-Medical students from the American-British system
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